ATG5 and central nervous system cancer: Furthermore, there is a growing body of literature that recognizes the importance of potential applications of autophagy related proteins, including LC3, ATG7, ATG5, Beclin1, and SH3GLB1, as prognostic biomarkers in some tumors, like glioma, breast cancer, and colon cancer (Park et al., 2013; Lebovitz et al., 2015).