In addition to CML, ALL, glioblastoma, laryngeal squamous cell carcinoma, and pulmonary adenocarcinoma showed sensitivity to L-asparaginase, and autophagy was demonstrated to be activated through autophagosomes formation and the conversion of cytoplasmic LC3-I to membranal LC3-II (Zhang et al., 2016; Chen et al., 2017; Ji et al., 2017; Takahashi et al., 2017; Polak et al., 2019). Here, ASPG is linked to acute lymphoblastic leukemia.