Our results further implied that the disorder of reactive oxygen species (ROS) is one of the possible pathogenesis of sPD, through regulating the transcription of certain genes by altering the chromatin structure around those genes, encoding the protein of partially large ATP-dependent chromatin, remodeling complex SNF/SWI, and generating the alternatively spliced transcript variants encoding different isoforms containing CAG length polymorphism. Here, SMARCA1 is linked to Platelet storage pool disease.