Peripheral Aβ42 is highly correlated with brain amyloid pathology (Nakamura et al., 2018; Schindler et al., 2019; Doecke et al., 2020); whereas, several studies have indicated that the loss of WM integrity reflects early tau accumulation other than amyloid pathology (Strain et al., 2018). The gene discussed is MAPT; the disease is amyloidosis.