A similar role has been hypothesized for the higher frequency of synonymous SNPs in PHOX2B, associated with OSAS (Lavezzi et al., 2013) and SIDS (Weese-Mayer et al., 2004), the reduced PHOX2B expression with protein dislocated in the cytoplasm in neurons from SIDS specimens (Lavezzi et al., 2012), and a complete PHOX2B gene deletion in an apparent life threatening event (ALTE) patient (Jennings et al., 2012). This evidence concerns the gene PHOX2B and sudden infant death syndrome.