The TLR2 and TLR4 DAMP called Hsp60 level increases in the skin of both guttate (a type of psoriasis seen in children and young adults, which shows small, red, scaly, and teardrop spots on the skin but do not leave a scar) and plaque psoriasis (Seung et al., 2007[188]). The gene discussed is TLR4; the disease is psoriasis.