The stimulation of TLR2 in macrophages isolated from AD patients produce a low level of Th1/Th17 cytokines (IFN-γ, IL-12, and IL-17F) but a higher level of Th2 cytokine (IL-15) as compared to macrophages isolated from control human donors (Yang et al., 2020[225]). This evidence concerns the gene TLR2 and Alzheimer disease.