TLR2 and acne: TLR4 and TLR2 also play a crucial pro-inflammatory role in the pathogenesis of acne vulgaris (inflammation of hair follicles and accompanying sebaceous gland called inflammation of pilosebaceous units), which also involves Propionibacterium acne (P. acne) as a pathogen (Lai and Gallo, 2008[104]; McInturff and Kim, 2005[127]).