The exposure of the TLR7 and TLR8 agonist Aldara (5 % imiquimod) to the skin induces psoriasis plaque spreading via inducing IL-23, IL-17A, and IL-17F in the epidermis (Horváth et al., 2019[71]; van der Fits et al., 2009[214]). The gene discussed is TLR8; the disease is psoriasis.