TLR2 and skin neoplasm: Both keratinocytes and melanocytes are the crucial skin cells giving rise to skin cancers, and both express different TLRs described earlier, and these TLRs (TLR2, -3, -4, -7, and -9) further increase during skin cancer, including melanoma (Coati et al., 2016[26]; Goto et al., 2008[60]; Mittal et al., 2010[133]; Saint-Jean et al., 2011[173]).