TLR4 and melanoma: The TLR4 signaling inhibition through icariside II (a herbal product isolated from Herba Epimedii) in human melanoma A375 cells decreases pro-inflammatory cytokine levels along with the vascular endothelial growth factor (VEGF), an essential element for tumor-associated angiogenesis and induces their apoptosis (Wu et al., 2012[221], 2013[222]).