The role of these hybrids in human diseases is thought to create a susceptibility to chromosomal breakage (Nadel et al., 2015[95]) and Wiskott-Aldrich syndrome (Sarkar et al., 2018[108]), an immune-defective disease such as Friedreich's ataxia (Neil et al., 2018[97]), Amyotrophic Lateral Sclerosis 4 (ALS4) with a neurodegenerative disease and senataxin mutation (Grunseich et al., 2018[41]). This evidence concerns the gene SETX and amyotrophic lateral sclerosis type 4.