HLA-DRB1 and autoimmune disease: Thus, consistent with the findings in transgenic mouse BMDMs, 15-mer peptides 65–79*SE and 65–79*PE, corresponding to the TAHRs coded by DRB1 alleles that confer autoimmune disease risk or protection, respectively, recapitulated the differentially induced expression of M1 versus M2 macrophage polarization gene markers in an epitope-specific fashion.