For example, soluble 65–79*SE and peptidomimetics of the QKRAA motif have been found to be arthritogenic in mice51,56, whereas 65–79*PE has been shown to dominantly protect against arthritis in mice carrying a permissive haplotype57, consistent with the findings that allele HLA-DRB1*04:02 is dominantly protective against arthritis in both mice44 and humans58. Here, HLA-DRB1 is linked to Arthritis.