Following a 28-day AngII infusion, ~20% (3/15) of Ad-LacZ-infected ApoE–/– mice died early (within two weeks) due to AAA rupture and 33% (5/15) of the remaining ApoE–/– mice developed AAA, with a total AAA incidence of 53% (8/15). The gene discussed is APOE; the disease is triple-A syndrome.