Next, we measured COMP expression in the suprarenal aortas of AngII-infused ApoE–/– mice, a mouse model that displays multiple characteristics of human AAA.31 Reduced COMP levels were observed in the aortas of AngII-infused ApoE–/– mice at an early stage (7 days) (Fig. 1b). Here, AGT is linked to triple-A syndrome.