Interestingly, substantially reduced plasma COMP levels were observed in patients with AAA (124.9 (88.0, 158.7) ng/mL, n = 88) compared with the control ASO group (212.6 (127.3, 351.0) ng/mL, n = 88, P < 0.0001), whereas the latter group exhibited a similar level to healthy volunteers (221.9 (197.1, 316.7) ng/mL, n = 51, P = 0.1712), indicating a substantial decrease in the plasma COMP level in patients with AAA compared to the normal plasma level (Fig. 1a). The gene discussed is COMP; the disease is triple-A syndrome.