COMP and triple-A syndrome: Upon AngII stimulation, ~18.2% (2/11) of Ad-GFP-infected ApoE–/– mice died early (within two weeks) due to AAA rupture and 66.7% (6/9) of the remaining ApoE–/– mice developed AAA at 28 days, with a total AAA incidence of 72.7% (8/11), whereas only 26.7% (4/15) of Ad-COMP-EGF2-infected ApoE–/– mice exhibited AAA (Fig. 7d, e).