Next, we measured COMP expression in the suprarenal aortas of AngII-infused ApoE–/– mice, a mouse model that displays multiple characteristics of human AAA.31 Reduced COMP levels were observed in the aortas of AngII-infused ApoE–/– mice at an early stage (7 days) (Fig. 1b). This evidence concerns the gene APOE and triple-A syndrome.