LCN2 and chronic kidney disease: We next tested whether GP1 blunted recombinant mNGAL-induced expression of profibrotic/proinflammatory markers in mouse primary renal fibroblasts (MKF) and whether in vivo administration of GP1 in the 5/6 Nx CKD mouse model had a similar effect as that reported for Lcn2/NGAL gene inactivation13.