SERPINE1 and post-traumatic stress disorder: The opposite pattern was observed for PAI-1 which reached much higher concentrations in animals showing PTSD-like memories than in control mice (Fig. 3g, i; interaction time × treatment: F4,48 = 2.648, p = 0.0446; time: F4,48 = 8.863, p < 0.0001; treatment: F1,12 = 25.89, p = 0.0003) as also shown by the analysis of the area under the curve (Fig. 3h; t = 6.835, df = 12, p < 0.0001).