SERPINE1 and post-traumatic stress disorder: In this report, combining complementary in vitro/in vivo molecular and pharmacological approaches and the first mouse model recapitulating the two memory components of PTSD (i.e., emotional hypermnesia and contextual amnesia) [5], we show that a deregulation of the GMES signaling cascade in the dorsal hippocampus, triggered by an increase in GC-induced type 1 plasminogen activator inhibitor (PAI-1) levels, underlies the transition from a normal memory to a PTSD-like fear memory.