Indeed, CXCR3 antagonism has been associated with inflammatory and autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, systemic lupus erythematosus, chronic obstructive pulmonary disease, psoriasis, organ transplant rejection and graft-vs-host disease, asthma, and type 1 diabetes50. The gene discussed is CXCR3; the disease is chronic obstructive pulmonary disease.