KCNJ12 and myotonic dystrophy type 1: Among them, seven mis-spliced RNA have been identified in previous studies from human DM1 embryo, brain, skeletal muscle or heat tissues (TTN21, CAST21, PDLIM321,22, MAPT23, ABLIM113,24, MYOM125 and MBNL126), three have been identified in previous studies from transgenic mouse models (APT11A27, CACNA1D28 and MBNL229), one has been identified in iPSC-CM (ANK330), and two others that represent, to the best of our knowledge, novel alterations of alternative splicing (KCNJ12 and MYH10).