However, on multivariate analysis, only tricuspid regurgitation systolic velocity emerged as an independent predictor of prognosis after adjusting for age, gender, malignant etiology of PE, arterial oxygen saturation, systolic blood pressure, heart rate, estimated glomerular filtration rate, troponin levels, LVEF and NT-proBNP levels. This evidence concerns the gene NPPB and Tricuspid regurgitation.