On univariate analysis age, malignant etiology of PE, arterial oxygen saturation, systolic blood pressure, heart rate, estimated glomerular filtration rate, N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, troponin levest, left ventricular ejection fraction (LVEF) and tricuspid regurgitation systolic velocity–but not gender, RV dilation or TAPSE—were significantly associated with all-cause long-term mortality. The gene discussed is NPPB; the disease is Tricuspid regurgitation.