After multivariate analysis adjustment, however, only NT-proBNP levels and tricuspid regurgitation systolic velocity emerged as an independent predictors for adverse outcomes—even after adjusting for age, gender, malignant etiology of PE, arterial oxygen saturation, systolic blood pressure, heart rate, estimated glomerular filtration rate, troponin levels, LVEF and NT-proBNP levels (Table 3). The gene discussed is NPPB; the disease is Tricuspid regurgitation.