ANXA5 and gastric cancer: As shown in Fig. 4B,C, when GC cell lines were treated with 5 and 10 μM of SFN for 48 h, we observed a marked increase in the level of apoptosis following SFN treatment in GC cells, and ~ 12% and 15% of the cells were Annexin V positive, respectively, whereas only ~ 9.5% in the control group.