From the review of literature we directed our research towards certain risk factors: leukocytosis9,12, serum bilirubin, AST, ALT, ALP8,12, fibrinogen8, C-reactive protein13, wall thickening, presence of pericholecystic fluid/abscess, gas in the wall or lumen, intraluminal membranes, irregular or absent gallbladder wall and pericholecystic inflammation10–12,24–27. The gene discussed is GPT; the disease is abscess.