A few months later, a 55 years-old woman diagnosed with ovarian high-grade serous carcinoma tested negative for BRCA1/2 and PALB2 in a broad HBOC clinical panel (Ref.11 for the panel), however the same truncating variant c.1516G > T;p.E506* in MRE11A was identified (Fig. 1a,b). The gene discussed is PALB2; the disease is serous adenocarcinoma.