TGFA and osteoarthritis: Overall 6 of the 15 genomic risk loci for EWGSOP low grip strength have been previously associated (or are in LD) with osteoarthritis (rs143384 – GDF5, rs13107325 – SLC39A8, rs34464763 – C12orf60, rs2899611 - ALDH1A2, rs958685 – TGFA and rs79723785 - BRSK1), of which two are also linked to adiposity, a known risk factor for osteoarthritis29.