The set of 41 compartments inactivated in CLL were significantly enriched (p value = 0.006) in downregulated genes (n = 11) as compared to normal B cells and MCL samples, being the early B cell factor 1 (EBF1) a remarkable example (Fig. 5c, d and Supplementary Data 6). The gene discussed is EBF1; the disease is B-cell chronic lymphocytic leukemia.