Importantly, this gene contained several motifs for the TCF4 TF (Fig. 6d), which itself is overexpressed in CLL as compared to normal B cells29, suggesting in this particular example that TCF4 overexpression may lead to aberrant binding to KSR2 regulatory elements and a local remodeling of its 3D interactions. The gene discussed is TCF4; the disease is B-cell chronic lymphocytic leukemia.