To obtain insights into the mechanisms underlying EBF1 silencing in CLL, we analyzed in detail a 2 Mb region hosting the gene, which also contains two nearby protein-coding genes, RNF145 and UBLCP1, and a lncRNA, LINC02202. We observed that a large fraction of 3D interactions involving the EBF1 region in normal B cells were lost in CLL resulting in a change from A-type to I-type compartment and a sharp inactivation of the gene, as shown by the analysis of chromatin states (Fig. 5e). This evidence concerns the gene EBF1 and B-cell chronic lymphocytic leukemia.