In MCL, although two groups based on the IGHV mutational status can be recognized and partially correlate with clinical behavior, other markers such as expression of the SOX11 oncogene are used to classify cases into clinically aggressive conventional MCL (cMCL) and clinically indolent non-nodal leukemic MCL (nnMCL)23,26–28. This evidence concerns the gene SOX11 and mantle cell lymphoma.