Different mechanisms sustain tumor escape as the reduced immune recognition of tumors due to the absence of tumor antigens, or the loss of MHC-I and related molecules, the increased resistance of tumor cells edited by the immune responses, and the development of a favorable TME associated with the presence of immunosuppressive cytokines and growth factors (such as VEGF, TGF-β) or the expression of checkpoint inhibitors such as PD-1/PD-L111. Here, TGFB1 is linked to neoplasm.