We clustered tumors of 80 patients with all stage (I-IV) of lung adenocarcinoma according to P2RX7 expression and showed that high levels of P2RX7 expression correlated with an increased immune response in LUAD patients, characterized by a high mRNA expression of CD274 (PD-L1), IL1B, IL18, a signature of primed cytotoxic T cells (defined by CD8A, CD8B, IFN-G, GZMA, GZMB, PRF1) (Fig. 7a). Here, IL1B is linked to lung adenocarcinoma.