MLKL and Thrombocytopenia: Furthermore, the recovery from antibody-mediated thrombocytopenia in Mlkl−/− mice was similar to that in wild-type control mice, indicating that stress-induced platelet production was unaffected by loss of Mlkl. We further generated mice with a conditional deletion of Mlkl in the megakaryocytic lineage and demonstrated that platelet count and other peripheral blood counts in MlklPf4Δ/Pf4Δ, mice were comparable to littermate controls, with no change in megakaryocyte numbers or morphology compared to floxed control mice.