The strongest statistical evidence for an association with progressive CLL was for rs736456 (hazard ratio (HR) = 1.76, 95% confidence interval (CI) = 1.45–2.14; P = 1.26 × 10−8), which maps to the TACC2 locus on chromosome 10q26.13 (Fig. 2). Here, TACC2 is linked to B-cell chronic lymphocytic leukemia.