DHODH and neoplasm: As shown in Fig. 1b, DHODH immunoreactivity was mainly observed in the perinuclear region, which was in line with previous reports showing mitochondrial localization of this protein.11 Notably, strong or moderate staining of DHODH was detected in tumor tissues; in contrast, most of non-cancerous tissues showed relatively weak DHODH signal (P < 0.001).