The abnormal expression of SOX2, probably due to increased copy number in genome, is associated with multiple tumor types, including OSCC.30 It is reported that upregulation of SOX2 is associated with a more aggressive phenotype of OSCC cells, and rendered OSCC cells resistant to chemotherapy.31 In this study, our data underscores the role of SOX2 in the reprogramming of pyrimidine synthesis, through depicting its regulation of DHODH transcription. Here, SOX2 is linked to neoplasm.