In conclusion, the rod dysfunction of fast photoresponse kinetics is present in many animal models of retinal degeneration [RhoG90D/+ mice (Sieving et al., 2001); RhoP347LorS/+ pigs (Kraft et al., 2005); Rho+/− mice (Lem et al., 1999; Calvert et al., 2001; Liang et al., 2004); and RPE65−/− (Woodruff et al., 2003)]. Here, RPE65 is linked to retinal degeneration.