KIT and gastrointestinal stromal tumor: Due to KIT proto-oncogene or platelet-derived growth factor receptor α (PDGFRα) mutations in GIST [5, 6], targeted therapy using imatinib mesylate (Gleevec®, Novartis Pharmaceuticals, Basel, Switzerland), a selective inhibitor of KIT and PDGFRα proteins, has been shown to prolong recurrence-free survival (RFS) in those at high risk for recurrence when used in an adjuvant therapy setting [7].