The two main neuropathologic features of AD, the accumulation of beta-amyloid in senile plaques (SPs) and microtubule associated protein tau (tau) in neurofibrillary tangles (NFTs) are variably labelled by silver stains [63], which allowed Braak and Braak to describe their progression through stereotyped neuroanatomical stages [7], with NFTs starting from the localized transentorhinal stage I. In contrast to SPs, the load of NFTs shows good correlation with clinical severity, duration of disease and neuronal loss [2, 3, 25]. This evidence concerns the gene MAPT and Alzheimer disease.