Staining of the alveus/stratum oriens and the white matter by tau-PLA and alignment onto axonal morphologies were prominent at early AD stages, as well as at the striatal pencil fibers in P301S mice, suggesting—unsurprisingly given tau functions to stabilize axonal microtubules—this early trigger may occur in axons [15, 29]. This evidence concerns the gene MAPT and Alzheimer disease.