We found no histone methylation differences among the other most common mutational findings typical of AML, regardless of whether they are associated with a functional change in DNA methylation regulating genes (TET2, IDH1/2, DNMT3A) or independent of methylation function (NPM1, TP53, PTPN11, Additional file 5: Table S1). This evidence concerns the gene PTPN11 and acute myeloid leukemia.