Taken together, these results suggested that hnRNP A2B1 regulated the pre-mRNA splicing of pro-apoptosis genes (DAPK1, SYT7, and RNF128) and anti-apoptosis genes (EIF3H, TPPP3, and DOCK2), thus leading to the suppression of apoptosis of cancer stem cells (Fig. 4h). The gene discussed is RNF128; the disease is cancer.