As shown in Fig. 1b, the expression profiles of hnRNP I and hnRNP L proteins were similar in MDA-MB-435 melanoma stem cells and non-stem cells, while the hnRNP A2B1 protein was significantly upregulated in melanoma stem cells compared with non-stem cells (Fig. 1b). The gene discussed is HNRNPA2B1; the disease is melanoma.