To explore the influence of hnRNP A2B1 on the expression levels of TPPP3, EIF3H, DOCK2, DAPK1, RNF128, and SYT7 in melanoma stem cells, hnRNP A2B1 was silenced or overexpressed, followed by the evaluation of gene expression levels. The gene discussed is DAPK1; the disease is melanoma.