The results showed that the tumor sizes were significantly reduced in mice injected with melanoma stem cells transfected with hnRNP A2B1-shRNA compared with those in mice treated with hnRNP A2B1-shRNA-scrambled (Fig. 5b), indicating that the hnRNP A2B1 shRNA suppressed tumor development in vivo. This evidence concerns the gene HNRNPA2B1 and neoplasm.