RNF115 and neoplasm: Similarly, compared to the control at day 33, RNF115 knockdown (shRNF115 1#) significantly (P < 0.001) decreased the tumor weight in mice (Fig. 3c), while RNF115 overexpression (oeRNF115) significantly (P < 0.001) increased the tumor weight in mice (Fig. 3h).