In addition, through TUNEL, we observed that the rate of tumor cell apoptosis in mice was significantly (P < 0.01) elevated by RNF115 knockdown (shRNF115 1#) (Fig. 3e) but significantly (P < 0.01) suppressed by RNF115 overexpression (oeRNF115) (Fig. 3j). This evidence concerns the gene RNF115 and neoplasm.