In order to determine the functional roles of RNF115 in tumor cells in vivo, we have established two types of mice models: (1) H358 cells with RNF115 knockdown (shRNF115) subcutaneously injected mice and (2) H1299 cells with RNF115 overexpression (oeRNF115) subcutaneously injected mice. The gene discussed is RNF115; the disease is neoplasm.