For examining the effectiveness of RNF115 on tumor cell proliferation and apoptosis, we have established two types of LUAD cells: (1) RNF115 knockdown in the cell lines (H358 and H1957) with relatively higher expression of RNF115 (Figs. 2a and S1B) and (2) RNF115 overexpression in the cell line (H1299) with relatively lower expression of RNF115 (Figs. 2f and S1C). Here, RNF115 is linked to neoplasm.