RNF115 and neoplasm: Additionally, the simultaneous treatment of β-catenin inhibitor or overexpression of β-catenin could counteract the promotive effect of RNF115 overexpression in LUAD cellular activities (Fig. 6), which further confirms the participation of RNF115 in tumor cell proliferation, programed cell death, and energy metabolism via Wnt/β-catenin signaling pathway.