STAT3 and ischemia: Compared with curcumin, cur-hydrogel can effectively improve cardiac function (FS,EF), inhibit left ventricular dilatation, inhibit ventricular remodeling and collagen synthesis, and activate JAK2/STAT3 pathway to protect injured myocardium in rat ischemia-reperfusion model, which may become a feasible scheme for clinical treatment of myocardial infarction.