Interestingly, the gene expressions of certain signal proteins, such as TLR7, MyD88, MDA5, MHCII, and Fc receptor, decreased in HD11 cells and PBMCs-Mφ at 12 hpi, respectively, indicating that IBV could inhibit the immune regulatory function of macrophages at the early stage of its infection. This evidence concerns the gene TLR7 and infection.