Accordingly, subsequent development of SAR408701 was mainly focused on patients with CEACAM5-positive non-squamous NSCLC, and three ongoing trials are investigating it as monotherapy (CARMEN-LC03), in association with ramucirumab (CARMEN-LC04) or as first-line therapy in combination with PD-1 (CARMEN-LC05) are ongoing (Table 2). This evidence concerns the gene CEACAM5 and non-small cell lung carcinoma.