In a study by Chen et al. [65], the antioxidant activities of the formulation were evaluated in in vitro models of SCA17 using HEK 293 and SH-SY5Y cells expressing mutant TATA-box binding protein (TBP), and in vivo transgenic mouse model of SCA17 overexpressing TBP. This evidence concerns the gene TBP and spinocerebellar ataxia type 17.