PPARGC1A and autosomal dominant cerebellar ataxia: In contrast, knockdown of PGC-1α and/or NRF2 promoted aggregation and attenuated the anti-aggregation activity of Shaoyao Gancao Tang, G. jasminoides and G. inflata, which suggest PGC-1α and NRF2 are involved in the positive effects on SCA [58, 59, 65].