In glioblastoma, we observed that both METTL3 and METTL14 are highly expressed compared to normal brain; additionally, we found that the A-to-I overall editing is decreased in GBM [10, 27], despite the high levels of ADAR1 protein found in this type of tumor (Fig. 1). The gene discussed is METTL14; the disease is glioblastoma.