ADAR and glioblastoma: To this aim, we first investigated which ADAR1 isoform is important for cell proliferation by generating glioblastoma cells (U87MG) stably transfected with an inducible vector expressing a dox-inducible shRNA targeting the 3′UTR of ADAR1. Then, we performed serial rescue experiments in these cells with the endogenous ADAR1 knocked down, re-introducing either p150 ADAR1 (active and the E/A catalytically inactive), p110 ADAR1 (active and the E/A catalytically inactive), or ADAR1 RNA-binding domain-mutated (RBDs-mut, unable to bind dsRNAs).