ADAR and neoplasm: Finally, in order to demonstrate that the ablation of ADAR1 when guided by external stimuli (such as lentivirus, compound, drug, DOXY, etc.)can inhibit tumor growth in vivo, we injected subcutaneously in the flanks of NOD-SCID mice (n = 16) the not induced glioblastoma cells (either shscr or shADAR1) and then, once the tumor mass started to growth, we treated the mice with DOXY (in drinking water) to induce, over time, the expression of shscr and the shADAR1 (Fig. 7a).