ADAR and glioblastoma: Then, we performed an ADAR1 rescue experiment (ADAR1 p110 and ADAR1 p110 E/A) in shMETTL3 cells and we found that ADAR1, independently of its active deaminase domain, is sufficient to recover proliferation of glioblastoma shMETTL3 cells at a level similar to control levels (Fig. 5e), demonstrating that METTL3 mediates cell proliferation through ADAR1.