AKT1 and neoplasm: In mouse EL4-Axl T lymphoma cells, Axl receptors mediate the expression of LIGHT through the PI3K/Akt/Sp1 axis and promote the secretion of immunocyte regulatory factors such as chemokine C–C motif ligand 5 (CCL5) and its receptor CCR5, thereby enhancing cytotoxic T lymphocytes (CTLs) and NK cells activity in the TME, leading to the suppression of tumor [127].