CASP2 and posterior cortical atrophy: This distinct chromosome conformation disease signature for PCa comprised of chromosomal interactions in five genomic loci: ETS proto-oncogene 1, transcription factor (ETS1), mitogen-activated protein kinase kinase kinase 14 (MAP3K14), solute carrier family 22 member 3 (SLC22A3) and caspase 2 (CASP2) (Table 1).