The finding of current study confirmed the findings of previous studies that some factors affect PLWHA's QoL: coinfection, availability, ARV, compliance with ARV, CD4 number, social support, occupation, gender, stigma, and depression rate (Atkins et al., 2010; Fatiregun et al., 2009; Folasire et al., 2012; Loutfy et al., 2015; Odili et al., 2011; Parslow et al., 2004; Razavi et al., 2012). This evidence concerns the gene CD4 and depressive disorder.