Several factors affecting PLWHA's quality of life are, among others: coinfection, availability, ARV, compliance with ARV, CD4 number, social support, occupation, gender, stigma, and depression rate (Atkins et al., 2010; Fatiregun, Mofolorunsho, & Osagbemi, 2009; Folasire, Irabor, & Folasire, 2012; Loutfy et al., 2015; Odili, Ikhurionan, Usifoh, & Oparah, 2011; Parslow, Jorm, Christensen, Jacomb, & Rodgers, 2004; Razavi et al., 2012). This evidence concerns the gene CD4 and depressive symptom measurement.