Aberrant expression of genes in the Hedgehog (Hh) pathway and its members (Ptch-1, Gli-1, and Gli-2) is a pivotal defect implicated in the pathogenesis of BCC, while overexpression of p63, a member of the p53 family, is often observed in SCCs (37–39). The gene discussed is GLI1; the disease is skin basal cell carcinoma.