BECN1 and neoplasm: The function of BHRF1, the EBV encoded homolog of the autophagy inhibitor anti-apoptotic protein BCL2 [19], has not been explored but the homologs encoded by the Kaposi sarcoma virus (KSHV) and murine herpesvirus-68 (MH68) were shown to inhibit autophagy by forming stable complexes with BECN1 [20], which may impair BECN1-mediated tumor suppression and promote oncogenesis.