Besides the safety issue, allele-specific editing performed in vitro demonstrated a robust knockdown of p.Pro347Ser RHO expression that significantly improved the viability of cells stably expressing the p.Pro347Ser rhodopsin, supporting the idea that degradation of p.Pro347Ser RHO protein in vivo could ameliorate the RP phenotype. Here, RHO is linked to retinitis pigmentosa 1.