To examine whether genes expressed by clonal neoantigen-reactive T cells could help further elucidate the drivers of CPI response, we performed single-cell RNA sequencing (RNA-seq) on ex vivo CD8 TILs from a treatment-naive NSCLC patient (L011) sorted according to positivity for a clonal neoantigen (MTFR2) multimer (as previously described; McGranahan et al., 2016). The gene discussed is CD8A; the disease is non-small cell lung carcinoma.