Urothelial carcinoma had the highest number of CCND1 amplified tumors (Figure 6B); accordingly we assessed mRNA levels in this histology type and observed significantly higher levels of CCND1 expression in urothelial cancer nonresponders (SD/PD) versus responders (PR/CR) (p = 1.5 × 10−2) (Figure 6C). Here, CCND1 is linked to urothelial carcinoma.