MYC and cancer: In biophysical studies therefore a shortened version (Pu22) is used to facilitate investigations (Figure 1).[17] It was shown that G4‐stabilizing ligands binding to Pu22 can downregulate c‐Myc transcription.[15] Further, the c‐Myc protein‐dependent proliferation can be inhibited, leading to inhibition of cancer cell growth.[18]