Differences between controls and CAD patients were detected in six SNPs located in ATM, CTLA4, BRCA1, CCND3, HRas and IL2. Differences between controls and UBCa patients were detected in six SNPs located in ABCC5, CDH13, CRP, CTLA4, p2 and TNFSF1 Differences between controls and LCa patients were detected in three SNPs located in DNMT3B, MTHFR, and Serpin1. The gene discussed is CTLA4; the disease is Leber congenital amaurosis.