In a prospective study performed in human patients with reperfused STEMI with inflammation biomarker kinetics over 30 days, our study had three main findings: 1) intramyocardial hemorrhage is significantly related to systemic inflammation with a strong association with pro-inflammatory biomarkers (IL-6, fibrinogen, neutrophils count, CRP); 2) persistent microvascular obstruction was also associated with greater levels of inflammatory biomarkers but this association seemed to be weaker. This evidence concerns the gene IL6 and hemorrhage.