It is possible that the impact of the CXCR4/SDF-1 axis is more prominent in patients with lymph node metastasis, or after recurrence, as this pathway is implicated in cell migration, invasion, and possible homing to different organ sites of metastases [4, 7, 8, 19]. This evidence concerns the gene CXCR4 and metastatic malignant neoplasm in the lymph nodes.