In addition, Cell division cycle 20 (CDC20), Cyclin-dependent kinase 4 (CDK4), minichromosome maintenance 6 (MCM6), MAD2L1, minichromosome maintenance 2 (MCM2) and minichromosome maintenance 5 (MCM5) were leading genes that intersected in these four pathways, and their mRNA expression levels were positively correlated with LACTB in most normal and cancer tissues. The gene discussed is CDK4; the disease is cancer.