Until recently, Keckesova et al. showed that LACTB was a tumor suppressor and inhibited the proliferation and promoted the apoptosis of breast cancer cells by inhibiting the proliferation of many types of breast cancer cells, and LACTB has the ability to change mitochondrial lipid metabolism and regulate the differentiation of cancer cells through this reprogramming, which is achieved through the LACTB-PISD-LPE/PE signaling axis. This evidence concerns the gene PISD and breast cancer.