Among the matched samples in this analysis, COPD 3 was of particular interest, as this specimen demonstrated strong cytoplasmic IL-33 signal in tissue, an intense CTD-reactive 28 kDa band on Western blot, and the highest IL-33 protein level measured in BW by ELISA (highlighted in yellow, Figure 4, C and E). The gene discussed is IL33; the disease is chronic obstructive pulmonary disease.