These results are in accordance with literature as PVT was said to be associating the advanced liver disease with severe ascites and liver cirrhosis with the documented reduced levels of protein S. While, the MTHFR heterozygous mutation, ATIII deficiency, and VFL were more frequent with negative JAK2 rs V617F mutation and no significant differences were reported regarding the other thrombophilia risk factors, demographic and clinical data with JAK2 mutation in patients with PVT. Here, MTHFR is linked to liver disorder.