Sharma et al., (2016) reported that low levels of AT III and proteins C and S have been reported in cirrhotic; but, it is not certain if this is true inherited thrombophilia or acquired from liver disease in contrast to these result a meta-analysis by Qi et al., (2013) showed that ATIII and proteins C and S levels are not significantly related to the development of PVT in cirrhosis. This evidence concerns the gene PROS1 and thrombophilia.