In alternative (non-canonical) NF-kB signaling pathway, APRIL (a proliferation-inducing ligand) as one of the members of the tumor necrosis factor (TNF) family bind to tumor necrosis factor receptor (TNFR) such as TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) and BCMA (B-cell maturation antigen) and causes proliferation, survival and protection CLL cells from apoptosis (Mackay and Ambrose, 2003; Haiat et al., 2006). The gene discussed is TNF; the disease is B-cell chronic lymphocytic leukemia.