BRCA1 and breast carcinoma: Additionally, bilateral salpingo-oophorectomy, typically after completion of child-bearing and between the age of 35–40 with BRCA1 variants and 40–45 with BRCA2 variants, reduces the risk of ovarian cancer by as much as 80% and has a mortality benefit [41]; it may also reduce the risk of breast cancer, although these data are inconsistent [41, 42].