In agreement, Loss of CEC-4 suppressed the muscle phenotype associated with a point mutation (LMN-Y59C) mimicking human Emery-Dreifuss muscular dystrophy (EDMD) in a C. elegans model [62], thus suggesting a connection between the H3K9me heterochromatin-anchoring machinery and lamin. Here, LMNB1 is linked to Emery-Dreifuss muscular dystrophy.